Hyperactivity

...ba href=/hyperactivity/a/b disorder (ADHD) in children and teenagers though it is effective against ADHD.

Cephalon Inc.’s Modafinil is being marketed as Provigil for treating sleep disorders.

The company is seeking to sell the drug under the name Sparlon for children with ADHD.

The ADHD version of the drug, generally known as modafinil, would be a smaller tablet and come in a wider range of doses.The FDA panel of foreign experts said it was most concerned about a possible link with skin rashes that can lead to hospitalization and recommended that the drug’s manufacturer, Cephalon Inc., conduct a 3,000-patient trial to measure the risk.

The drug is as well found in link with aggression, mania and other possible psychiatric effects.Wayne Goodman, panel chairman and a psychiatrist at the University of Florida said, "I think we’re dealing with some fuzzy information," adding that some more clinical studies are required before the approval.

He said, "I don’t want to do that experiment in the post-marketing arena."Earlier the panel granted the conditional approval for the ADHD use in October 2005, but sought its expert advice over tarriance concerns about the rashes as well as mania, aggression and other possible psychiatric effects.This is another setback for Cephalon, which has faced obstacles with its experimental sleep disorder drug Nuvigil as well as the Vivitrol alcoholism treatment it is developing with Alkermes Inc.Thomas Laughren, FDA’s Director of Psychiatry Products said, "They’d hav...

...ba href=/hyperactivity/a/b disorder drug made by rival Cephalon that could have posed a threat to Shire's Adderall XD.

Cigarette manufacturer Gallaher was on its way up on rumours of consolidation hit the sector.

Brokers cited the group as a possible bid target for Japan Tobacco.

Otherwise the miners extended yesterdays gains with Anglo American leading the charge.

BHP Billiton and Xstrata were also in demand.

Radio group GCAP Media has scrapped plans to sell off nine analogue stations and also to pay out a special dividend with the proceeds.

The group added that revenues for the quarter ending March fell by approximately 17%, year on year, and for the year are down by 13%.

Savings from the merger have come through quicker than expected, the group added, compensating for the lower forecast revenue.

House of Fraser's full year underlying profits rose by 4.6% to £27.3m.

The first seven weeks the current year are ahead of expectations, the department store group added.

Engineer 600 has that warned due to some contracts now not likely to complete until the first half of next year, overall underlying profit will be close to break-even for the year ending March.

Paperboard and plastic packaging firm Robinson is predicting further progress in the year ahead but cautioned price pressures are likely to continue.

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- - Visit Digital Look for more financial data and tools TSCO - Tesco Latest Prices Name Price % Tesco 346.25p +3.44% Anglo American 2,132.00p +2.60% BHP Billiton 1,014.00p +2.32% C...

...ba href=/hyperactivity/a/b drug, which would have competed with several products being developed by the UK company.

Analysts at Deutsche Bank said the news is positive for three ba href=/hyperactivity/a/b drugs that Shire is hoping to launch.

Elsewhere, Carnival rebounded 92 pence higher to 2,942 following falls in reaction to first quarter results yesterday, aided by Deutsche Bank reiterating its 'buy' advice and 4,500 pence price target on the cruise operator.

And on the M&A front, Gallaher was today's speculative target, up 21-1/2 pence to 869-1/2 as rumours circulated again that the tobacco firm could be a bid target for Japan Tabacco.

Oil heavyweights lent support, as crude prices edged closer to the 64 usd mark on the back of weaker than-expected US inventories.

BP took on 11 pence at 666-1/2, and Royal Dutch Shell added 23 pence at 1,829.

Miners also found favour, building on gains in Australia overnight, on yet another spike in commodity prices as copper hit all time highs.

Xstrata jumped 50 pence to 1,881, Rio Tinto took on 32 pence at 2,805, BHP Billiton was up 27-1/2 pence at 1,098-1/2, and Anglo American gained 57 pence at 2,135.

Anglo American was also in focus after the group revealed it is to further reduce its stake in AngloGold to 42.6 pct via a placing of 27.9 mln shares.

And Antofagasta rallied from earlier falls, adding 16 pence at 2,091 thanks to the copper price gains.

Traders had been fretting that the group might get dragged into a bidding war over Australian-listed Tethyan...