Insomnia

Almost half of Seroquel sales in 2006 were for disorders for which AstraZeneca has yet to gain regulatory approval, according to Datamonitor Plc, a London-based market research firm.

The other half was for approved indications such as treating schizophrenia and for bi-polar disorder, also known as manic depression, according to Terence McManus, a Datamonitor analyst.

The amount of off-label use is ``across the class,'' McManus said in an interview March 6.

Seroquel sales increased 24 percent in 2006 to $3.4 billion.

Revenue may jump 30 percent more this year to $4.4 billion, according to David Seemungal, an analyst at Standard & Poor's Equity in London.

He estimates that Seroquel sales of London- based AstraZeneca will peak in 2010 at $5.75 billion.

`Policies in Place' ``We have policies in place that provide direction around the appropriate promotion of our product,'' said Jim Minnick, an AstraZeneca spokesman.

Lilly's spokeswoman Carole Puls said the drugmaker doesn't promote off-label use.

Johnson & Johnson spokesman Srikant Ramaswami declined to comment on why off-label use is increasing.

``We promote our products only for their FDA-approved indications, and we support scientific and clinical studies that advance what is known about our products,'' he said.

J&J shares added 42 cents to $62.14 at 4:00 p.m.

in New York Stock Exchange composite trading.

Bristol-Myers slipped 24 cents to $26.92 in...

The trial will evaluate the long-term efficacy and safety of the medication in seniors.

To be eligible to participate, volunteers must be between the ages of 65 and 85, and have difficulty falling and staying asleep.

The study will involve up to nine visits to the Clinical Trials Center during an approximately 18-week period.

During that time, volunteers will be evaluated for improvement in the quality of sleep and next-day ba href=/insomnia/a/b symptoms.

Qualified participants will receive study-related medical care, laboratory work and study medication at no cost.

Compensation for time and travel also is available.

For more information or to find out if you are eligible, call the Clinical Trials Center at 516-663-9582 or e-mail clinicaltrials@winthrop.org.

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That group organized such turbulent protests as those during the Mar del Plata Summit in November 2005, which Bush attended for a couple of hours.

The US president arrives in Uruguay tonight, as part a Latin American tour he began Thursday in Brazil, to include Colombia, Guatemala, and Mexico.

Top police and army officers have expressed concern over the numerous marches and activities against the US president´s visit, and have prepared security during the demonstrations.

Thousands of Brazilians protested in Sao Paulo yesterday, with posters along the main avenues reading “Bush Out of Iraq.” The rallies, supported by Lula´s leftist PT (Workers´ Party) and other movements, ended up in clashes with the police.

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