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APD356 (Obesity) Clinical Program Update Arena recently received results from its chronic twelve and six-month pre-clinical toxicology studies of APD356, its orally administered, internally discovered drug candidate for the treatment of obesity.

The toxicology studies did not demonstrate any apparent drug effect on heart valves or pulmonary vasculature, and Arena continues to expect to initiate the APD356 Phase 3 program in the second half of 2006.

"We are very encouraged by the results of these toxicology studies, which provide additional evidence of the favorable safety profile of APD356 emerging from the clinical and pre-clinical data," commented William Shanahan, M.D., Arena's Vice President and Chief Medical Officer.

"Demonstrating chronic pre-clinical safety is important in the development of any drug." An abstract discussing the Phase 2b clinical results of APD356 has been selected for an Oral Presentation at the American Diabetes Association's 66th Annual Scientific Sessions in Washington, D.C., and is scheduled to be presented on June 12, 2006.

APD125 (ba href=/insomnia/a/b) Clinical Program Update Arena also recently received correspondence from the FDA seeking clarification of certain nonclinical issues in its IND application for APD125, which seeks approval to conduct a Phase 2 clinical trial in patients with chronic ba href=/insomnia/a/b.

Arena believes that the issues raised by the FDA may be resolvable using available data, but the FDA may require Arena to generate additional ...

...ba href=/insomnia/a/b, disturbed sleep like sleep apnea and excessive sleep such as narcolepsy.Another common sleep problem happens around this time of the year.

During daylight-saving time, which begins the first Sunday in April, an hour of sleep is lost.“There are ways to prepare for this so it doesn't cause disturbances in everyday life,” Galvanek said.

“A few days prior, try to get more sleep than usual.

Gradually advance your sleep schedule by going to sleep and waking up 15 minutes earlier for about three or four days before the start of daylight-saving time.”To help deal with the time change, as well as sleep in general, people should do the following:€ Create a sleep-conducive environment that is dark, quiet, comfortable and cool€ Establish a regular bedtime and wake time schedule€ Try a relaxing routine like soaking in hot water before bedtime€ Exercise regularly, but complete the workout at least a few hours before bedtime€ Avoid caffeine, nicotine and alcohol close to bedtime, as they can disrupt sleep€ Use the bedroom for sleep; leave problems at the door and try to unwind before bedtimetberkebile@cadillacnews.com | 775-NEWS (6397) Email this story Submit your opinion Print this story !

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...ba href=/insomnia/a/b drug, which would delay starting a mid-stage study until the fourth quarter.

Such a delay, however, would not affect the company's longer-term timeline of applying in 2009 for approval for the drug, APD125, Arena said.

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