Insomnia

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Almost half of Seroquel sales in 2006 were for disorders for which AstraZeneca has yet to gain regulatory approval, according to Datamonitor Plc, a London-based market research firm.

The other half was for approved indications such as treating schizophrenia and for bi-polar disorder, also known as manic depression, according to Terence McManus, a Datamonitor analyst.

The amount of off-label use is ``across the class,'' McManus said in an interview March 6.

Seroquel sales increased 24 percent in 2006 to $3.4 billion.

Revenue may jump 30 percent more this year to $4.4 billion, according to David Seemungal, an analyst at Standard & Poor's Equity in London.

He estimates that Seroquel sales of London- based AstraZeneca will peak in 2010 at $5.75 billion.

`Policies in Place' ``We have policies in place that provide direction around the appropriate promotion of our product,'' said Jim Minnick, an AstraZeneca spokesman.

Lilly's spokeswoman Carole Puls said the drugmaker doesn't promote off-label use.

Johnson & Johnson spokesman Srikant Ramaswami declined to comment on why off-label use is increasing.

``We promote our products only for their FDA-approved indications, and we support scientific and clinical studies that advance what is known about our products,'' he said.

J&J shares added 42 cents to $62.14 at 4:00 p.m.

in New York Stock Exchange composite trading.

Bristol-Myers slipped 24 cents to $26.92 in...

...ba href=/insomnia/a/b and even depression.

For them it may take days - even weeks - to get their sleep habits back on track.

Greenberg offers a simple tip for them and anyone else who wants some help drifting off in the wee hours.

Basically, let there be light.

"Just getting up and making sure you're walking around in a brightly lit kitchen or bedroom for about 20 to 30 minutes can make all the difference," he says.

The American Academy of Sleep Medicine, meantime, offers some other daylight-saving time tips: * Start readjusting your sleep schedule early - days prior to the time change - by going to bed an hour earlier.

(And don't forget to have dinner an hour earlier, too.) * Be especially careful driving or operating machinery the day of the time change.

* Avoid napping, particularly just before bedtime.

* Avoid using caffeine in the morning to wake up or alcohol at night to aid sleep.

* Keep your schedule light the Monday after the time change.

Minimize driving and avoid strenuous physical activities.

* Eat properly, stay well hydrated and remain physically active.

* Rod Antone can be reached at 577-7628 or at rantone@yakima-herald.com Sponsors Fundraising Buy LCD TVs Online Shopping WEATHER Weather Center Pass Cams/Updates !

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...ba href=/insomnia/a/b, dizziness, or memory loss that respond to selective serotonin reuptake inhibitors [SSRIs], Prozac being the most famous and Lexapro the most currently prescribed, that functionally increase serotonin activity."Page: 1 Next Related WebsitesMyHeartCentral.com - Get detailed information on heart disease.

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