The World's 10 Best-Selling Drugs

...ba href=/insomnia/a/b drug made by Sepracor (nasdaq: SEPR - news - people ).

And there are more on the way he says are worth watching.

The two key drug launches this year are of Sutent, Pfizer's first big entry into cancer drugs, and Acomplia, the anti-obesity pill being developed by Sanofi-Aventis.

Sutent is already on the market, although sales data are not yet available.

Acomplia has been delayed at the U.S.

Food and Drug Administration and rejected as a stop-smoking drug.

Some cardiologists, who are excited about the drug because of its potential to reduce the risk of heart disease, are also worried about side effects.

Acomplia works by blocking the same brain receptor that makes pot smokers hungry; psychiatric symptoms like anxiety are one of the most common reasons patients stopped taking Acomplia in clinical trials.

"It's a pill that blocks the 'happy receptor'," worries Prediman K.

Shah of Cedars Sinai Medical Center.

"The main reason for concern is that it might have an adverse impact on depression or suicide." He is nonetheless very excited about the pill.

Click here for a slide show of the top ten best-selling drugs.

More On This Topic Pfizer's $13 Billion Bind Special Report The Best-Selling Drugs In America 2005 Special Report World's Top 10 Drugs 2004 Companies: PFE GSK !

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You can count on Frankie of Paradise

... Baxter Bulletin - www.baxterbulletin.com - Welcome to The Baxter Bulletin, Mountain Home, Arkansas Customer Service: Subscribe Now Contact Us baxterbulletin.com Weather Calendar Jobs Cars Homes Shopping Classifieds Dating Search 7 days Archive Home News Local News Election 2006 Archives Obituaries Local Sports Opinion Weather State News Nation/World Travel Technology RSS Feeds Entertainment Communities Directories Customer Service ADVERTISEMENT ADVERTISEMENT ADVERTISEMENT You can count on Frankie of Paradise It's tax time for Cloud Creek Institute For The Arts, the non-profit corporation that eats all the money paid me by this fine newspaper — and then some — and that can mean only one thing:Frankie Fitzgerald.

ADVERTISEMENT Frankie is Paradise's sole CPA.

He may even be the only one in the county.

The difference between the way Frankie looks in, say, August, and the way he looks during tax season in March and April is the difference between day and night, beauty and the beast, or Al Pacino in "The Godfather" and Al in "ba href=/insomnia/a/b." I mean, this man works until he drops.

I'm not the world's greatest judge of accountants, but it seems to me that Frankie knows his stuff.

More important than his expertise, though, is his personality.

From the minute I met him, I loved him.

I felt good being around him.

Warm.

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In good hands.

Some people's body language says, "Stay away!

" His say...

THYROID MEDICINE MAKES HER SICK

...ba href=/insomnia/a/b, tremors and the rest.

You have two options: One is to take a smaller dose of Synthroid; the other is to take no medicine and wait until the signs of hypothyroidism (sluggish thyroid gland) appear.

People with a gland that's not making enough thyroid hormone eventually develop chronic tiredness, dry skin, brittle hair, constipation, menstrual irregularities, memory lapses and a feeling of being cold all the time.

The symptoms don't come on suddenly.

You'll know when they start, and then you will know it's time to take Synthroid.

The thyroid booklet deals with both an underactive and overactive thyroid gland.

Readers can obtain a copy by writing: Dr.

Donohue - No.

401, Box 536475, Orlando, FL 32853-6475.

Enclose a check or money order (no cash) for $4.75 U.S./$6.75 Can.

with the recipient's printed name and address.

Please allow four weeks for delivery.

DEAR DR.

DONOHUE: Something strange happened to me last week.

All of a sudden, I found it impossible to get words out of my mouth.

I knew what I wanted to say, but I couldn't say it.

At the same time, I was unstable - I couldn't keep my balance.

My husband says it was a faint.

What's your opinion?

- G.K.

ANSWER: You make a good case for a TIA, a transient ischemic attack.

It's a temporary interruption of blood flow to the brain.

The symptoms disappear when blood flow resumes.

The danger of a TIA is that it can be an omen that a stroke is about to happen.

About 10 percent of people who have had a TIA will have a stro...

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